After appearing in the 2003 film Dickie Roberts: Former Child Star, she played Colby Chandler on the daytime soap opera All My Children from 2006 to 2008. She also played Elizabeth “E” Dodd in The Master. Childers and Kate Bosworth teamed up to co-create Ambyr Childers Jewelry, a new line of delicate pieces that mixes Childers’s Native American heritage with Bosworth’s “essential cool-girl vibe”. Childers starred as Candace Stone in Lifetime’s television adaptation of You, which premiered on September 9, 2018. On December 3, 2018, it was announced that You would move to Netflix as a “Netflix Original” title, ahead of the premiere of the second season. On February 1, 2019, Deadline announced that Childers had been promoted to a series regular role, ahead of the second season’s premiere. The second season was released on December 26, 2019.