Shiri jumped in front of the lens as a youngster appearing in Norman Lear Sunday Dinner and Lawrence Kasden's I Love You To Death. At 19 she had her breakout performance on the series Roswell, playing the leading role of Liz Parker. She went on to appear in ER, Six Degrees, as well as Mike Nichols' Charlie Wilson's War, HBO's GIRLS, CW's Life Unexpected, before starring in Lifetime's critically acclaimed dramady UnReal, playing Rachel Goldberg, a producer working behind the scenes of a dating competition show, which received the Peabody Award. In 2016, Shiri was nominated for a Critics Choice Award for Best Actress for her work on the show. Shiri directed four episodes of UnReal before focusing most of her attention on directing. Shiri has directed shows such as Minx, UnPrisoned, Blackish, New Amsterdam, Young Sheldon, and many others, across all platforms.